Significant reductions in the risk of mild cognitive impairment (MCI), and the combination of MCI and dementia, have been shown for the first time through aggressive lowering of systolic blood pressure in new research results from the federally-funded SPRINT MIND Study reported at the Alzheimer's Association International Conference (AAIC) 2018 in Chicago.
 

"This is the first randomized clinical trial to demonstrate a reduction in new cases of MCI alone and the combined risk of MCI plus all-cause dementia," said Jeff D. Williamson, MD, MHS, Professor of Internal Medicine and Epidemiology and Chief, Section on Gerontology and Geriatric Medicine at Wake Forest School of Medicine. Williamson reported these results at AAIC 2018. The results of this large-scale, long-term clinical trial provide the strongest evidence to date about reducing risk of MCI and dementia through the treatment of high blood pressure, which is one of the leading causes of cardiovascular disease worldwide.

"This study shows more conclusively than ever before that there are things you can do - especially regarding cardiovascular disease risk factors - to reduce your risk of MCI and dementia," said Maria C. Carrillo, PhD, Alzheimer's Association Chief Science Officer. "To reduce new cases of MCI and dementia globally we must do everything we can - as professionals and individuals - to reduce blood pressure to the levels indicated in this study, which we know is beneficial to cardiovascular risk."

Carrillo pointed out that these results fit well with recent population data showing reductions in new cases of dementia in developed Western cultures. These lower rates of dementia may be occurring as these societies have begun to improve control of cardiovascular disease risk factors through medication management, reducing smoking, and greater awareness of healthy lifestyle.

"The future of reducing MCI and dementia could be in treating the whole person with a combination of drugs and modifiable risk factor interventions - as we do now in heart disease," Carrillo suggested. "These new blood pressure findings raise our level of anticipation for the U.S. POINTER Study, which includes managing cardiovascular disease risk factors as part of the multi-component lifestyle intervention."

The Alzheimer's Association U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) is a two-year clinical trial funded by the Alzheimer's Association to evaluate whether lifestyle interventions can protect cognitive function in older adults at increased risk for cognitive decline. The interventions include physical exercise, nutritional counseling and modification, cognitive and social stimulation, and improved self-management of health status.

Intensive Blood Pressure Control Significantly Reduces New Cases of MCI, and Combined Risk of MCI and Dementia: SPRINT MIND Study At AAIC 2018, Williamson and colleagues reported preliminary results related to risk of dementia and cognitive decline from the Systolic Blood Pressure Intervention Trial (SPRINT).

SPRINT is a randomized clinical trial that compared two strategies for managing high blood pressure (hypertension) in older adults: an intensive strategy with a systolic blood pressure goal of less than 120 mm Hg versus a standard care strategy targeting a systolic blood pressure goal of less than 140 mm Hg.

Previously, SPRINT demonstrated that more intensive blood pressure control reduced the risk for cardiovascular morbidity and mortality (NEJM, 11-26-15). SPRINT helped inform the 2017 American Heart Association and American College of Cardiology high blood pressure clinical guidelines.