Liong EM, McDonald CM, Suh J, et al. - In this 10-wk zinc-controlled feeding trial, it was inquired how zinc-biofortified wheat intake can impact plasma zinc levels as well as biomarkers of zinc-dependent functions. Participants were 36 healthy adult men, aged 18 to 51 y. Firstly, there was a 2-wk run-in period [metabolic period (MP) 1] (9.3 mg zinc/d and 2.1 g total phytate/d) to standardize zinc status, thereafter, participants were asked to eat bread made from zinc-biofortified wheat (10.9 mg zinc/d) with no additional phytate (0.6 g/d total phytate) for 6 wk (MP2). A 25-mg zinc supplement was daily consumed by half of the men during the final 2 wk (MP3), to ascertain whether the supplement further changed zinc status biomarkers. Findings revealed alterations in FADS(fatty acid desaturase)2 and FADS1 activities as a result of a 1.6-mg/d increase in dietary zinc from biofortified wheat in healthy adult men, however, DNA damage, plasma zinc, or glutathione levels remained unaffected by this dietary intervention, this demonstrates more sensitivity of FADS activities to small alterations in zinc consumed with a meal.