Hanson BM, Tao X, Zhan Y, et al. - As predictable patterns of methylation are followed by the majority of human tissues, which can be determined throughout a person’s lifetime, researchers here examined if and how poor ovarian response is linked with a change in predicted age based on a DNA methylation-derived age prediction model (the Horvath algorithm) in white blood cells (WBCs) or cumulus cells (CCs). They conducted a prospective cohort study including 175 women undergoing ovarian stimulation. Grouping of women was done according to a poor (≤ 5 oocytes retrieved) or good (> 5 oocytes) response to ovarian stimulation. They performed placement of those with polycystic ovary syndrome (PCOS) (n = 35) in the good responder group. The participants were assessed for DNA methylation patterns from WBC and CC. Consistent with patients’ chronologic age, the Horvath-predicted age for WBC samples was reported. Overall findings revealed correlation of poor ovarian response with epigenetic age acceleration within WBC samples, but not with age-related changes in CC, in young women.