Chung GE, Cho EJ, Yoo JJ, et al. - In young adults, myocardial infarction (MI) and stroke can be independently predicted by nonalcoholic fatty liver disease (NAFLD). Based on this study’s findings, emphasizing primary prevention of cardiovascular disease in young adults with NAFLD is advised.

• From the Korean National Health Insurance Service, a total of 5,324,410 adults who were aged 20 to 39 years when they had a health examination were included in this population-based cohort study.

• A fatty liver index (FLI) ≥ 60 (used to define NAFLD) was detected in 9.8% of participants.

• Multivariable analysis revealed a higher risk of MI and stroke in relation to NAFLD (hazard ratios [HRs] were 1.69 and 1.73, respectively).

• Dose-dependent links of MI and stroke with FLI were found (HR 1.28 in those with FLI 30-59 and 1.73 in those with FLI ≥60 for MI and HR 1.18 in those with FLI 30-59 and 1.41 in those with FLI ≥60 for stroke, respectively).