Gómez-Mayordomo V, Palacios-Ceña M, Guerrero-Peral A, et al. - Researchers examined the prevalence of widespread pressure pain hypersensitivity among men with episodic cluster headache (CH) in a long-lasting remission phase. A blinded assessor assessed PPTs bilaterally over 1 trigeminal (temporalis muscle) and 3 extra-trigeminal points (C5/C6 zygapophyseal joint, second metacarpal, tibialis anterior muscle) in 40 men with episodic CH and 40 matched controls. Assessment of patients was done in a prolonged remission phase, at least 6 months after their last CH attack and without taking any medication. Relative to headache-free individuals, patients with CH exhibited significantly decreased PPTs bilaterally over the temporalis muscle (mean difference: 85 to 100 kPa), C5/C6 zygapophyseal joint (mean difference: 65 to 80 kPa), second metacarpal (mean difference: 65 to 90 kPa), and tibialis anterior muscle (mean difference: 135 to 155 kPa). This suggests bilateral widespread hypersensitivity to pressure pain during long-lasting remission periods among patients with CH, which was not linked with depression or anxiety. Results thereby confirm the persistence of central sensitization in episodic CH, even in remote asymptomatic phases.