Hoevenaars FPM, Esser D, Schutte S, et al. - Researchers examined the influence of whole grain wheat (WGW) consumption on health by quantifying the body's resilience, defined as the “ability to adapt to a standardized challenge”, in this double-blind randomized controlled trial including overweight and obese (BMI: 25–35 kg/m²) men (n = 19) and postmenopausal women (n = 31) aged 45–70 y, with mildly raised plasma total cholesterol (> 5 mmol/L). Either WGW (98 g/d) or refined wheat (RW) was consumed by the participants for 12 wks, using randomized allocation. A standardized mixed-meal challenge was carried out prior to and following the intervention. They assessed intervention results as composite markers representing the resilience of inflammation, liver, and metabolism, using health space models. RW was shown to induce diminished inflammatory and liver resilience, whereas WGW rejuvenated liver resilience, by health space visualization. Findings revealed the capability of 12-wk 98 g/d WGW intake in promoting liver and inflammatory resilience in overweight and obese people with mildly raised plasma cholesterol. To assess intervention impacts as composite markers, the health space approach seemed suitable.