Bennell KL, Nelligan RK, Kimp AJ, et al. - The efficacy of two exercise programs were directly compared for people with medial knee osteoarthritis (OA) and co-morbid obesity. A participant- and assessor-blinded randomized controlled trial was designed to include a total of 128 people ≥ 50 years with medial knee OA and body mass index ≥ 30 kg/m2. Change in overall knee pain (numeric rating scale, range 0–10) and difficulty with physical function (Western Ontario and McMaster Universities Osteoarthritis Index, 0–68) over 12 weeks were the primary endpoints. Other pain measures, physical function, quality-of-life, global changes, physical performance, and lower-limb muscle strength were considered as secondary endpoints. The results of this study indicate that both exercise types similarly improved primary outcomes of pain and function and can be considered for people with knee OA and obesity. The data considered that weight bearing exercise may be preferred given fewer adverse events and potential future advantages on some secondary outcomes.