Zou Z, Yan X, Li C, et al. - In this systematic review and meta-analysis involving 994 patients, researchers explored the association between von Willebrand factor (vWF) antigen and hepatic venous pressure gradient (HVPG) and assessed the diagnostic performance of vWF to identify clinically significant portal hypertension (CSPH) and severe portal hypertension (SPH). As a novel biomarker, vWF has a moderate HVPG correlation and shows satisfactory performance in the diagnosis of CSPH and SPH in cirrhosis patients. In terms of vWF's ability to detect SPH, the pooled sensitivity and specificity were 86% and 75% respectively.