Hahn RG, et al. - Given that general anesthesia induction raises the hemodilution induced by infusion of crystalloid fluid, which is believed to be because of slower distribution resulting from arterial hypotension, and there is no idea about when normal distribution returns, so to inquire this, researchers undertook this study with volunteers. Overall 25 volunteers who underwent general anesthesia induction for open abdominal hysterectomy were administered an intravenous infusion of 25 mL kg^− 1 of Ringer’s lactate, infused over 30 min just after induction. They employed mixed-effects modelling software to fit a two-volume model to the repeated measurements of the blood hemoglobin level and the urinary excretion. Individual-specific covariates were added in sequence. Findings revealed that general anesthesia induction interrupted the distribution of lactated Ringer’s solution up to when 16.6 mL kg^− 1 of crystalloid fluid had been infused. During this period of time, experts noted that plasma volume expansion was pronounced.