Hoyt M, et al. – In this study involving participants of the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening Trial, researchers assed the development of prostate cancer in relation to dietary intake of phylloquinone (vitamin K-1), menaquinones (vitamin K-2), and total vitamin K, during a median follow-up of 11.8 years. From 28,356 men who completed the Dietary Questionnaire (DQX) and 48,090 men who completed the Dietary History Questionnaire (DHQ), 2,978 (including 490 advanced cases) and 2,973 cases of prostate cancer (including 647 advanced cases) were identified. Cox proportional hazards regression was used to estimate the risk of prostate cancer in relation to vitamin K dietary intake. Findings revealed no significant link of dietary intakes of phylloquinone, menaquinones, and total vitamin K, assessed with either the DQX or DHQ, with the risk of advanced, nonadvanced, and total prostate cancer after adjustment for confounders. Overall, the occurrence of total and advanced prostate cancer in the general US population was not influenced by vitamin K intake.