Hoyt M, et al. – In this study involving participants in the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening Trial, researchers assessed the development of prostate cancer in association with dietary intake of phylloquinone (vitamin K-1), menaquinones (vitamin K-2), and total vitamin K using high-performance liquid chromatography–based food-composition data from the USDA and published studies. Median follow-up of 11.8 years, during which time 2,978 cases of prostate cancer (including 490 advanced cases) were identified from the 28,356 men who completed Dietary Questionnaire (DQX), as well as 2,973 cases (including 647 advanced cases) from the 48,090 men who completed Dietary History Questionnaire (DHQ). Findings revealed no significant association of dietary intakes of phylloquinone, menaquinones, and total vitamin K (assessed with either the DQX or DHQ) with the risk of advanced, nonadvanced, and total prostate cancer after adjustment for confounders. Overall, the occurrence of total and advanced prostate cancer in the general US population was unaffected by vitamin K intake.