Robinson SL, et al. - Researchers focused on behavior problems in adolescence in correlation with vitamin D deficiency (VDD) and vitamin D binding protein (DBP) in middle childhood. Plasma total 25-hydroxyvitamin D and DBP were quantified in 273 schoolchildren aged 5–12 y at recruitment into a cohort investigation in Bogota, Colombia. Following a median 6-y follow-up, the evaluation of externalizing and internalizing behavior problems was done using parental report [Child Behavior Checklist (CBCL)] and self-report [Youth Self-Report (YSR)]. They found an adjusted 6.0 (95% CI: 3.0, 9.0) and 3.4 (95% CI: 0.1, 6.6) units higher CBCL and YSR externalizing problems scores, respectively, and an adjusted 3.6 (95% CI: 0.3, 6.9) units higher CBCL internalizing problems scores in correlation with VDD. Compared with children without VDD, those with VDD exhibited 1.8 (95% CI: 1.1, 3.1) times higher prevalence of clinical total externalizing problems. In relation to DBP level below the population median, higher YSR aggressive behavior and anxious/depressed subscale scores, as well as higher prevalence of clinical total externalizing problems, were reported. As concluded by experts, VDD and low DBP in middle childhood were associated with behavior problems in adolescence.