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Vitamin D and falls in older African American women: The PODA randomized clinical trial

Journal of the American Geriatrics Society Mar 21, 2019

Aloia JF, et al. - In the PODA trial, researchers investigated the impact of maintaining serum 25(OH)D levels > 30 ng/mL on fall prevention in healthy black women aged > 60 years with serum 25(OH)D levels 8-26 ng/mL. The study sample consisted of 260 women; a total of 184 completed the 3-year trial. Participants were randomized to receive either placebo or active vitamin D. The investigators used a double-dummy design and adjusted vitamin D3 dose to maintain serum 25(OH)D levels above 30 ng/mL in the active group. Falls were reported for 46% and 47% of participants in treatment and placebo groups, respectively. Findings revealed no link between serum 25(OH)D levels or vitamin D dose and risk of falling. Overall, compared with the Institute of Medicine recommendation (20 ng/mL), maintaining serum 25(OH)D above 30 ng/mL yielded no benefit in terms of preventing falls in healthy older black women.

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