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Visuospatial dysfunction is associated with posterior distribution of white matter damage in non-demented cerebral amyloid angiopathy

European Journal of Neurology Jun 27, 2021

Su Y, Fu J, Zhang Y, et al. - This study was undertaken to determine if the visuospatial dysfunction in cerebral amyloid angiopathy (CAA) is correlated with the posterior distribution of small vessel disease (SVD) imaging markers. Sixty non-demented CAA cases were recruited from a Chinese prospective cohort and 30 cases with non-CAA SVD served as controls. The authors used the Visual Object and Space Perception battery to assess visuospatial abilities, and multivariable regression models to evaluate their relationships with SVD imaging markers. Results revealed that there was visuospatial dysfunction particularly the visual object perception impairment in CAA than controls. This finding suggests that posterior white matter damage rather than global disease severity may be a major contributor to CAA visuospatial dysfunction.

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