Sinclair LI, et al. - Given that dementia with Lewy bodies (DLB) is more commonly accompanied by visual hallucinations (VH) and the involvement of reduced perfusion of the occipital lobe has been suggested in DLB patients with VH, and both reduced cholinergic activity and reduced oxygenation of the occipital cortex in DLB has been indicated in post-mortem investigations, therefore, researchers analyzed brain tissue acquired post-mortem from 23 Alzheimer disease (AD) patients who had experienced visual hallucinations, 19 AD patients without hallucinations, 19 DLB patients, and 36 controls, to evaluate microvessel density, ante-mortem oxygenation, cholinergic innervation, butyrylcholinesterase and insoluble α-synuclein content in the Brodmann area 18 and 19 occipital cortex. They matched cohorts for age, gender and post-mortem interval. Findings revealed the link of VH in AD with cholinergic denervation rather than with chronic hypoperfusion or α-synuclein collection in visual processing regions of the occipital cortex.