Borrego-Sanz L, Gómez-Gómez A, Gurrea-Almela M, et al. - Researchers undertook this retrospective longitudinal cohort analysis to compare the clinical prognosis among selected white dot syndromes (WDS) (birdshot chorioretinopathy (BRC), multifocal choroiditis, serpiginous choroidopathy (SC), and others), as well as to determine factors that confer risk for poor visual prognosis. This study included 84 patients (143 affected eyes) diagnosed with WDS selected from three Uveitis Clinics (Madrid Community, Spain). The greatest incidence rates (IR) of vision loss was shown by SC even in the multivariate models. The worse visual prognosis was demonstrated by past events of vision loss, the presence of choroidal neovascularization, and cataracts. Higher IR of visual loss was reported in relation to monotherapy with immunosuppressive drugs but not combine therapy. The highest IR of epiretinal membrane and macular edema was demonstrated by BRC. Overall, the worst visual prognosis was observed in SC. Patients with WDS who carry the risk of a worse clinical evolution could be detected via some ocular manifestations.