Dai JY, et al. - Researchers examined the association between self-reported vigorous physical activity and prostate cancer progression to a metastatic–lethal phenotype in a Seattle-based cohort of patients diagnosed with clinically localized prostate cancer (n = 1,354). Outcomes revealed significantly less frequent progression to metastatic–lethal prostate cancer among patients who had vigorous physical activity at least once per week during the year before diagnosis (around 79% of the cohort) vs those who had less frequent vigorous physical activity. This supports the association between vigorous physical activity and a lower likelihood of developing metastatic-lethal progression. Further, they identified a possible link between exercise and DNA methylation in the CRACRA2A gene (a gene that encodes a calcium-binding protein involved in innate immune response).