Clark GRC, Anderson AS, Godfrey TG, et al. - Since the incidence of colorectal cancer (CRC) in developed countries has declined in the over 50 years age group but increased in younger people, researchers analyzed CRC incidence by age and the influence of screening uptake. From 1997 to 2017, age-standardised and sex-standardised incidences for CRC were obtained from the Scottish Cancer Registry (SCR). Furthermore, the linkage between the Scottish Bowel Screening Database and the SCR allowed investigation of any link between screening participation and CRC incidence. For this analysis, 2,395,172 were invited to participate from the introduction of screening in 2000 through to 2017, of which 1,487,999 took part at least once. CRC incidence peaked at 156.5 cases per 100,000 in 2010 in the screening age range (50–74 years) after full roll-out of screening across Scotland but fell to 123.9 per 100,000 in 2017. Within 50 years, however, there was a rise from 5.3 cases per 100,000 in 2000 to 6.8 per 100,000 in 2017. In Scotland, the incidence of CRC has decreased in the age group of over 50 years, but has risen in younger people. Population screening is likely to have led to the decrease in the incidence of CRC in the age group above 50 years.