Ma Y, Wolters FJ, Chibnik LB, et al. - In a prospective cohort study ongoing since 1989 in the Netherlands, 5,273 dementia-free people enrolled and assessed to ascertain whether blood pressure variation over a period of years, considering both magnitude and direction, is related to the risk of dementia. A large blood pressure variation, measured over 2 sequential visits every 4 years apart, was correlated with a heightened risk of dementia, particularly when this variation occurred long before the diagnosis. Both large rises and falls in blood pressure were related to greater long-term risk. Over a period of years, a large blood pressure fluctuation was related to an elevated long-term risk of dementia, according to findings. When this modification occurred long before diagnosis, the association between blood pressure fluctuation and dementia seemed most pronounced. Moreover, with both a large rise and fall in blood pressure, an elevated long-term risk of dementia was noted.