Shi W, Xing L, Jing L, et al. - Researchers undertook this cross-sectional analysis to examine the link between triglyceride-glucose index (TyG; recognized as a practical surrogate of insulin resistance in recent studies) and prevalent ischemic stroke, to ultimately determine the worth of TyG to optimize the risk stratification of ischemic stroke. Participants belonged to rural areas of northeast China and were 10,900 in total (mean age: 59.95 years, 59.8% females). They calculated TyG as ln[fasting triglyceride (mg/dl) × fasting plasma glucose (mg/dl)/2]. The prevalence of ischemic stroke was estimated to be 5.49%. With each SD increase of TyG, 22.8% additional risk for ischemic stroke was observed after adjusting for all covariates. For ischemic stroke, a 1.776 times risk was observed in the top quartile of TyG against the bottom category. Findings revealed a proportional correlation of the prevalent ischemic stroke with the increase of TyG, citing the linearity of TyG as an indicator of ischemic stroke. TyG was suggested to hold potential value to optimize ischemic stroke risk stratification in a general population.