Value of carotid ultrasound in cardiovascular risk stratification in patients with psoriatic disease
Arthritis & Rheumatology Sep 09, 2019
Sobchak C, Akhtari S, Harvey P, et al. - Via a cohort analysis, researchers evaluated whether subclinical atherosclerosis, as assessed by carotid ultrasound, could prognosticate incident cardiovascular events (CVEs) in patients with psoriatic disease (PsD) and ascertained whether inclusion of imaging data could enhance CV risk prognostication by the Framingham Risk Score (FRS). A total of 559 patients with PsD were evaluated, of whom 23 had incident CVEs discovered. During the study period, the calculated rate of developing a first CVE was 1.11 events per 100 patient-years. In patients with PsD, the total plaque area (TPA), mean carotid intima-media thickness (CIMT), maximal CIMT, and high TPA category were each predictive of incident CVEs when investigated separately in Cox proportional hazards models that were controlled for the FRS. In conclusion, the burden of carotid atherosclerosis is correlated with a heightened risk of developing future CVEs. Moreover, in patients with PsD, combining vascular imaging data with information on traditional CV risk factors could increase the accuracy of CV risk stratification.
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