DeVilbiss EA, Naimi AI, Mumford SA, et al. - Researchers investigated the predictive value of timing of bleeding and nausea symptoms for the risk of pregnancy loss among women with ultrasound-confirmed pregnancies. In the Effects of Aspirin in Gestation and Reproduction trial (2006–2012), enrollment of a cohort of 701 women with clinically confirmed pregnancies and 1 to 2 previous pregnancy losses was performed preconceptionally. Participants were asked to fill daily symptom diaries from 2 to 8 weeks’ gestation and were prospectively monitored for detection of pregnancy loss. Vaginal bleeding was reported in 211 participants (30.1%), and nausea was reported in 639 (91.2%) participants. Predictive value of nausea and bleeding for clinical pregnancy loss was similar to age, body mass index, blood pressure, and waist-to-hip ratio measured preconceptionally. Observations revealed an increased risk of clinical pregnancy loss among women experiencing bleeding without nausea between 6 and 8 weeks’ gestation. They indicated bleeding and nausea as not predictive risk factors of clinical pregnancy loss prior to 6 weeks’ gestation.