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Utility of routine spirometry measures for surveillance of idiopathic subglottic stenosis

JAMA Otolaryngology-Head & Neck Surgery Jan 23, 2019

Carpenter DJ, et al. - A total of 42 females (mean age, 51.5 years) affected with idiopathic subglottic stenosis without comorbid lower airway or parenchymal lung disease between 2014 and 2018 were examined to assess the utility of peak expiratory flow (PEF) as a biometric indicator of disease progression, with respect to other validated spirometry measures. Investigators measured PEF, expiratory disproportion index (EDI), and total peak flow (TPF) at preoperative visits and at all other visits. They observed the optimal cutoff value of 4.4 L/sec (264 L/min), with a sensitivity and specificity of 84.4% and 82.0%, respectively. They suggested PEF as a simple, effective, and convenient approach of monitoring the progress of idiopathic subglottic stenosis and prognosticating surgical intervention.

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