Loureiro-Amigo J, Palacio-García C, Martínez-Gallo M, et al. - This study was carried out to assess the usefulness of lymphocyte phenotype profile to differentiate primary sjögren syndrome from sicca syndrome. Researchers examined the distribution of peripheral lymphocyte subpopulations by flow cytometry in 68 patients with pSS, 26 patients with Sicca syndrome, and 23 healthy controls. Using the area under the curve of the receiver operating characteristic curve of the different lymphocyte subsets., the ability to discriminate between pSS and Sicca syndrome was examined. It was shown that individuals with pSS exhibit a profound imbalance in the distribution of circulating T and B lymphocytes subsets. It has been reported that the ratio B _NSM /CD4 _ACT is beneficial to discriminate between pSS and Sicca syndrome.