Thakur S, Yu M, Tham YC, et al. - In the present study, the researchers sought to assess the impact of signal strength (SS) on optical coherence tomography (OCT) parameters, and devise an algorithm to adjust the effect, when acceptable SS cannot be obtained. Five thousand eighty-five people (9,582 eyes), aged ≥ 40 years from the Singapore Epidemiology of Eye Diseases population-based study were involved. Everyone had a standardised ocular examination and imaging with Cirrus HD-OCT. Average retinal nerve fibre layer (RNFL) thickness displayed shift of 4.11 µm from SS of 5 to 6. By using an algorithm, OCT parameters can be adjusted for poor SS. This may potentially help in the diagnosis and monitoring of glaucoma if acceptable SS scans cannot be obtained from patients in clinics.