Chan YM, Lippincott MF, Barroso PS, et al. - Researchers performed a longitudinal cohort study to ascertain if responses to kisspeptin can predict outcomes for individuals with pubertal delay. The sample consisted of 16 children (3 girls and 13 boys) with delayed or stalled puberty. For clinical evidence of progression through puberty, children who had undergone kisspeptin- and GnRH-stimulation testing were followed every 6 months. According to results, all candidates who responded to kisspeptin with an increase in luteinizing hormone (LH) of 0.8 mIU/mL or greater subsequently progressed through puberty.  On the other hand, all participants who had shown LH responses to kisspeptin ≤ 0.4 mIU/mL had reached age 18 years without developing any physical signs of puberty. Consequently, responses to kisspeptin predicted accurately later pubertal outcomes. In addition, in predicting pubertal outcomes, the kisspeptin-stimulation test outperformed GnRH-stimulated LH, inhibin B, and genetic testing. The kisspeptin-stimulation can evaluate future reproductive endocrine potential in prepubertal children and is a promising novel method for anticipating pubertal outcomes for delayed puberty children.