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Using clinical characteristics and patient‐reported outcome measures to categorize systemic lupus erythematosus subtypes

Arthritis Care & Research Mar 12, 2021

Rogers JL, Eudy AM, Pisetsky D, et al. - This study was attempted to define the clinical manifestations of systemic lupus erythematosus (SLE) subtypes and to determine the correlation between the patient‐ and physician‐reported measures used in the model. Researchers designed a cross‐sectional study of patients with SLE in a university clinic. They distinguished 4 groups: type 1 SLE (active SLE without fibromyalgia), type 2 SLE (inactive SLE with fibromyalgia), mixed SLE (active SLE with fibromyalgia), and minimal SLE (inactive SLE without fibromyalgia). A total of 212 patients were included in this cohort (92% female, mean age 45 years), 30% had type 1 SLE, 8% had type 2 SLE, 13% had mixed SLE, and 49% had minimal SLE. The data exhibited that in SLE, fatigue, widespread pain, sleep dysfunction, and mood disorders are common symptoms. Distinguishing these symptoms as type 2 SLE may be a procedure to improve patient communication and understanding. Patients’ perception of disease and self‐reported symptoms were impacted by the level of type 2 SLE. It has been considered that the Systemic Lupus Activity Questionnaire may need to be reinterpreted based on the fibromyalgia severity scale.

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