Wihersaari L, et al. - Researchers examined how patient age and time from collapse to return of spontaneous circulation (ROSC) influence the prognostic accuracy of neuron specific enolase (NSE) after out-of-hospital cardiac arrest (OHCA). Serum concentrations of NSE were measured in 249 patients who were admitted to intensive care units after resuscitation from OHCA via electrochemiluminescence immunoassay. The investigators observed poor 12-month outcomes in nearly 50% of patients. In the youngest quartile (18-53 years of age), the prognostic performance of NSE was excellent, but with increasing age, it worsened; it was poor in the oldest quartile (aged ≥ 72 years). In the quartile with the shortest time to ROSC (1-13 minutes), the prognostic performance of NSE was worthless, but with increasing time to ROSC, the performance improved; it was good in the quartile with the longest time to ROSC (≥ 29 minutes).