Kim F, et al. - Researchers tested the hypothesis that survival will be improved by intravenous (IV) administration of sodium nitrite during resuscitation of out-of- hospital-cardiac arrest (OHCA). In this Phase 1 open-label study including patients with OHCA from ventricular fibrillation (VF) or non-VF initial rhythms by Seattle Fire Department paramedics, treatment impacts were compared between high and low dose nitrite groups, and to all patients in a concurrent local EMS registry of OHCA. No significant difference was noted between the low and high nitrite groups for rate of return of spontaneous circulation (ROSC), re-arrest in the field, use of norepinephrine, first systolic blood pressure, survival to discharge and neurologically favorable survival. These outcomes were not notably different between patients who received IV nitrite vs concurrent registry controls. Overall, it was feasible as well as appeared safe to administer IV nitrite in patients with OHCA.