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Use of varenicline and nicotine replacement therapy in people with and without general practitioner-recorded dementia: Retrospective cohort study of routine electronic medical records

BMJ Open Sep 06, 2019

Itani T, Martin R, Rai D, et al. - Using data from the Clinical Practice Research Datalink, researchers carried out a retrospective cohort study using electronic medical records from 683 general practices in England from 2007 to 2015 to estimate smoking prevalence and prescribing rates of varenicline and nicotine replacement therapy (NRT) in people with and without general practitioner (GP)-recorded dementia (aged 18 years), as well as to evaluate and compare quit rates of smokers with vs without GP-recorded dementia who were prescribed varenicline or NRT for smoking cessation. Of the 235,314 people involved in this analysis, 447 were people with dementia, whereas 234,867 were people without. Varenicline was less likely to be prescribed among people with GP-recorded dementia than those without dementia between 2007 and 2015. Quit rates were comparable in those with and without dementia following the prescription of either NRT or varenicline.
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