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Use of statins after ischemic stroke in young adults and its association with long-term outcome

Stroke Nov 24, 2019

van Dongen MME, Aarnio K, Martinez-Majander N, et al. - Researchers studied the use of statins, defined as at least 2 purchases, in young adults with ischemic stroke, a patient group with a known low burden of atherosclerosis, and its correlation with subsequent vascular events through adjusted Cox regression analyses. The sample consisted of 935 first-ever 30-day ischemic stroke survivors (aged 15 to 49 years) from the Helsinki Young Stroke Registry, 1994 to 2007. During follow-up, 46.8% of the 935 patients used statins at some point. Findings suggested a significant association of purchasing statins with higher age, dyslipidemia, heavy alcohol use, and hypertension. After adjustment for dyslipidemia, stroke subtype, and other confounders, statin users displayed a lower risk of all-cause mortality and recurrent stroke than nonusers. After propensity score–matched comparison, these findings remained unchanged.
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