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Use of statins after ischemic stroke in young adults and its association with long-term outcome

Stroke Nov 15, 2019

van Dongen MME, Aarnio K, Martinez-Majander N, et al. - In young adults with ischemic stroke, a patient group with a known low burden of atherosclerosis, researchers analyzed the use of statins (defined as at least 2 purchases) and its correlation with subsequent vascular events by adjusted Cox regression analyses. Participants in the study were 935 first-ever 30-day ischemic stroke survivors (aged 15 to 49 years) from the Helsinki Young Stroke Registry, 1994 to 2007. During follow-up, 46.8% of the 935 patients used statins at some point. Purchasing statins were significantly associated with higher age, dyslipidemia, heavy alcohol use, and hypertension. After adjustment for dyslipidemia, stroke subtype, and other confounders, statin users showed lower risk of all-cause mortality and recurrent stroke than nonusers. After propensity score–matched comparison, these findings remained unchanged.
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