Kim SJ, Kim N, Kim EH, et al. - The medical records of individuals who underwent lower extremity amputation (LEA) between September 2007 and August 2017, who were grouped according to use of general anesthesia (GA) or regional anesthesia (RA), were reviewed in order to ascertain the impact of anesthesia type on perioperative outcomes in individuals with diabetes and/or peripheral vascular disease undergoing LEA. For above-knee amputation, below-knee amputation, or more minor amputation, 519 individuals were recognized to have received GA (n = 227) or RA (n = 292). A correlation of GA with coronary artery disease, peripheral arterial disease, and preoperative treatment with aspirin and clopidogrel was found, prior to propensity score matching. Propensity score matching produced a cohort of 342 individuals evenly distributed between GA and RA. No important between-group variation in 30-day or 90-day mortality or postoperative morbidity was noted. Therefore, the type of anesthesia did not considerably influence mortality or morbidity following LEA. Nevertheless, with RA, intraoperative hypotension, vasopressor use, and postoperative ICU admission rates were lower.