Simonov M, Abel EA, Skanderson M, et al. - Whether and how proton pump inhibitor (PPI) use is related to kidney stones was examined in this retrospective analysis utilizing data from the Women’s Veteran’s Cohort Study. Data regarding PPI usage over time, demographics, laboratory findings, comorbidities, and medication usage were obtained from 465,891 patients. Use of histamine-2 receptor antagonists (H2RAs) was determined and levothyroxine use was a negative control exposure. Greater risk of kidney stones was observed in relation to increased dosage of PPI. Increased risk was also noted in correlation with H2RAs. In adjusted analysis, there was no link of levothyroxine use with kidney stones. Overall, PPI use was identified to be related to a dose-dependent rise in kidney stone risk in a large cohort study of veterans. Acid suppression may be an involved mechanism, due to the link between H2RA use and kidney stone risk. Prescribing for most patients will not need to be changes since the effect is small.