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Use of propofol for prevention of post-delivery nausea during cesarean section: A double-blind, randomized, placebo-controlled trial

Journal of Anesthesia Sep 15, 2018

Niu K, et al. - Researchers evaluated the antiemetic properties of propofol for the prevention and immediate treatment of post-delivery nausea and vomiting during in women (n=80) undergoing elective cesarean delivery under combined spinal-epidural anesthesia. Participants were randomized to propofol at a plasma concentration of 1000 ng/mL or normal saline treatment immediately after clamping of the umbilical cord. They performed intraoperative assessment of the incidence of post-delivery nausea and vomiting, patients requiring rescue antiemetic, bispectral index, sedation score, and the incidence of hypotension. Satisfaction and neonatal behavioral neurological assessments were assessed postoperatively. Findings revealed that, propofol at a plasma concentration of 1000 ng/mL vs placebo led to a remarkable attenuation in the incidence of post-delivery nausea but had no effect on reducing retching or vomiting episodes during cesarean section.

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