Elharrar X, Trigui Y, Dols AM, et al. - Researchers conducted a prospective, single-center, before-after study among awake, nonintubated, spontaneously breathing patients with COVID-19 and hypoxemic acute respiratory failure requiring oxygen supplementation with the aim to determine the feasibility, efficacy, and tolerance of prone positioning (PP) in these patients. Inclusion was performed of patients with confirmed COVID-19 if they (1) required oxygen supplementation and (2) had chest computed tomography findings suggestive of COVID-19 with posterior lesions. During the study, they maintained the same oxygen supply (device and fraction of inspired oxygen). Measurement of arterial blood gases was performed just before PP, during PP, and 6 to 12 hours after resupination. Among the recruited patients, 63% were able to tolerate PP for more than 3 hours. However, only 25% showed increase in oxygenation during PP and this increase was not sustained in half of those after resupination. These results are in line with findings from previous small studies of PP in nonintubated patients. They suggest making a trial of PP in order to determine patients who will do well or it may be useful in a subset.