Paje D, et al. - Through a prospective cohort study of 52 hospitals who enrolled in the Michigan Hospital Medicine Safety Consortium, the researchers intended to explain the frequency of and features correlated with peripherally inserted central catheters (PICCs) use in hospitalized subjects with stage 3b or greater chronic kidney disease (CKD) (glomerular filtration rate [GFR] <45 mL/min/1.73 m²). A total of 20,545 hospitalized medical patients who got a PICC between November 2013 and September 2016 were assessed. Four thousand seven hundred and forty-three out of 20,545, had a predicted GFR (eGFR) less than 45 mL/min/1.73 m² and 699 were observed undergoing hemodialysis. In the intensive care unit (ICU), 30.9% of patients who got PICCs had an eGFR less than 45 mL/min/1.73 m², however, in the wards, it was observed as 19.3%. In comparison to single-lumen PICCs, multilumen PICCs were placed more commonly in patients with an eGFR less than 45 mL/min/1.73 m². PICC-related complications happened in 15.3% of subjects with an eGFR less than 45 mL/min/1.73 m² and in 15.2% with an eGFR of 45 mL/min/1.73 m² or greater, in the wards. In ICU settings, the analogous percentages were 22.4% and 23.9%. PICC placement differed extensively across hospitals in patients with an eGFR less than 45 mL/min/1.73 m². Hence, placement CKD patients was concluded as common with no concordance with clinical guidelines, in this sample of hospitalized patients who underwent PICCs.