Terheyden JH, Schmitz-Valckenberg S, Crabb D, et al. - Researchers conducted a literature search for the use of composite endpoints as primary outcome measures in clinical studies of early age-related macular degeneration (AMD) stages. In total, 673 articles of interest were identified. There was an absence in the literature of sensitivity analyses of different endpoints against accepted outcomes (ie, progression). There have been various composite outcome measures used, but there is a lack of standardization. To date, there is no consensus on an appropriate strategy for the application of combined endpoints in early-stage clinical trials of AMD and no surrogate endpoints for AMD progression have been approved.