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Use of antimalarial drugs is associated with a lower risk of preeclampsia in lupus pregnancy: A prospective cohort study

International Journal of Rheumatic Diseases Apr 03, 2020

Saavedra MA, Miranda‐Hernández D, Lara‐Mejía A, et al. - Researchers determined risk factors correlated with preeclampsia in patients with systemic lupus erythematosus (SLE) and its effect on fetal outcomes. Between January 2009 and December 2018, a prospective cohort of pregnancies in women with SLE was studied. This study compared demographic, clinical, serological and drug use characteristics between patients who developed preeclampsia and those who did not, as well as the main neonatal outcomes. They conducted an adjusted logistic regression analysis to distinguish factors potentially correlated with preeclampsia. A total of 316 pregnancies of 20 or more weeks of gestation were studied. Results reveal that, during pregnancy, the use of antimalarial drugs decreases the risk of preeclampsia in lupus pregnancies.

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