Berge LAM, Andreassen BK, Stenehjem JS, et al. - This study was undertaken to investigate the relationship between the use of antidepressants and melanoma by using nation-wide data from the Cancer Registry of Norway, the National Registry, the Norwegian Prescription Database and the Medical Birth Registry of Norway. Researchers included all cases aged 18– 85 with a primary cutaneous invasive melanoma diagnosed during 2007– 2015 (n = 12,099) who were matched to population controls 1:10 (n = 118,467) by gender and year of birth using risk-set sampling. Between 2004 and 2015, they collected information on prescribed antidepressants and other potentially confounding drug use. They further applied conditional logistic regression to calculate adjusted rate ratios (RRs) and 95% confidence intervals (CIs) for the association between overall and class-specific use of antidepressants and incident melanoma. It was shown that the use of antidepressants was correlated with a decreased risk of melanoma. There are at least two possible explanations for the outcomes; cancer-inhibiting actions produced by the drug and less UVR exposure among the most frequent users of antidepressants.