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Use and reporting of outcome measures in randomized trials for anti-neutrophil cytoplasmic antibody-associated vasculitis: A systematic literature review of randomized trials

Seminars in Arthritis and Rheumatism Nov 10, 2020

Monti S, Quinn KA, Christensen R, et al. - A systematic literature review of randomized trials was designed to evaluate the use and reporting of outcome measures in randomized trials for anti-neutrophil cytoplasmic antibody-associated vasculitis. Researchers performed a systematic literature review of outcome measures (as specified in the methods section as primary and/or secondary outcomes) in randomized controlled trials (RCTs) of ANCA-associated vasculitis (AAV). They carried out to search Medline, Cochrane CENTRAL, and ClinicalTrials.gov from inception until April 30, 2019, for RCTs enrolling patients with granulomatosis with polyangiitis and/or microscopic polyangiitis. 68 RCTs, out of 1101 identified records, were eligible for this study. The data revealed that outcome measures applied in AAV trials commonly included vasculitis-specific tools for disease assessment, but with heterogeneity in endpoint-definitions and timing of assessments. It was indicated that other core outcomes in AAV, including PROs, and damage measures, are often omitted in AAV trials.

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