Malhotra R, Katz R, Jotwani V, et al. - Among SPRINT (Systolic Blood Pressure Intervention Trial) participants with nondiabetic CKD, researchers evaluated the link between urinary kidney tubule injury markers at baseline and subsequent loss of kidney function. Applying Cox proportional hazards models, the links of the aforementioned markers with the kidney composite outcome of 50% eGFR reduction or ESKD necessitating dialysis or kidney transplantation, were assessed. A median follow-up of 3.8 years revealed 87 kidney composite outcome events. In fully adjusted models including baseline eGFR and urine albumin, a higher risk of the kidney composite outcome was observed in relation to the highest quartiles of urinary kidney injury molecule-1, monocyte chemoattractant protein-1, and YKL-40 (human cartilage glycoprotein-40) vs the respective lowest quartiles. Urinary IL-18 was identified as the only marker related to eGFR drop, in linear analysis, and this finding was stronger in the standard arm of SPRINT. Overall, it was concluded that urine markers of tubule cell injury afford knowledge regarding the risk of subsequent loss of kidney function, beyond the eGFR and urine albumin.