Welsh CE, et al. - Researchers assessed links between sodium excretion, blood pressure, and incidence of fatal and nonfatal cardiovascular disease, heart failure, and mortality in subjects without cardiovascular disease, treated hypertension, or diabetes mellitus at baseline (n=322,624). Patients with urinary electrolytes and blood pressure data were identified from the UK Biobank (n=457,484; mean age, 56.3 years; 44.7% men). A total of 11,932 deaths (1,125 cardiovascular deaths) and 10,717 nonfatal cardiovascular events were reported over a median follow-up of 6.99 years. Findings revealed no link between outcomes and quintile of sodium excretion; across sodium excretion quintiles, the risk of incident heart failure did not change. In subjects at low cardiovascular risk, a correlation of urinary sodium excretion with elevated blood pressure was evident. With either high or low sodium consumption, no pattern of increased cardiovascular disease, heart failure, or mortality risk was shown.