Sjaarda LA, Radoc JG, Flannagan KS, et al. - The present study was conducted to explore if any relationship exists between selective serotonin reuptake inhibitor (SSRI) exposure through specific time points of pregnancy establishment with fecundability and pregnancy loss. Applying longitudinal urine measurements of common SSRIs while women are actively trying to conceive, researchers designed this prospective cohort study. The study included 1,228 women without uncontrolled depression/anxiety who were attempting natural conception while participating in a randomized trial of preconception-initiated low-dose aspirin. This study’s findings demonstrate that women who use SSRIs may have more trouble becoming pregnant. A 24% reduced fecundability and a nonsignificant 9% lower live birth incidence was correlated with SSRI exposure; a significantly reduced incidence of live birth was seen in fluoxetine-exposed women. Fluoxetine deserves caution and future study, although SSRI exposure overall was not correlated with pregnancy loss.