Wang H, et al. - Researchers conducted the study for analyzing the value of urinary orosomucoid 1 protein (UORM1) in early renal impairment screening in type‐2 diabetes (T2D) individuals. Among 406 T2D patients, the concentration of UORM1, the UORM1‐to‐creatinine ratio (UORM1CR), the urinary albumin‐to‐creatinine ratio (ACR), the alpha‐1‐microglobulin‐to‐creatinine ratio (A1MCR) and estimated glomerular filtration rate (eGFR) have been measured. Bad glycaemic control posed the highest risk of increased UORM1CR, whereas high HDL‐C (high‐density lipoprotein cholesterol) reduced the risk of increased UORM1CR. For the early screening of renal impairment in T2D individuals, the UORM1CR (> 3.69 mg/g) has the high diagnostic efficiency. In addition, good glycaemic control and high HDL‐C could be protective factors against UORM1CR increase.