van de Luitgaarden IAT, Beulens JWJ, Schrieks IC, et al. - Using the Prevention of Renal and Vascular End-Stage Disease cohort, researchers assessed whether ethyl glucuronide (EtG) can serve as a reliable indicator for habitual alcohol intake vs self-report and other biomarkers in the general population. They analyzed 24-hour urine samples from 6,211 participants to determine EtG levels. Levels ≥ 100 ng/mL meant a positive EtG. The observed sensitivity, positive predictive value, and negative predictive value were 66.3%, 96.3%, and 47.4%, respectively. The proportion of positive and negative agreement was 78.5% and 62.7%, respectively. A linear association of EtG levels with higher categories of alcohol intake was noted, adjusted for age, sex, and renal function. A positive association of EtG with mean corpuscular volume, HDL cholesterol, and γ-glutamyltransferase, but not with aspartate aminotransferase and alanine aminotransferase levels, was reported. Overall, urinary EtG reasonably agrees with self-reported alcohol intake and thus can serve as an objective marker of habitual alcohol consumption in the general population.