Jotwani VK, et al. - Researchers investigated if a higher risk of cardiovascular disease (CVD) and mortality could be seen in chronic kidney disease (CKD) patients relative to urinary biomarkers of tubular injury, inflammation, and repair. Among 2,377 participants of the Systolic Blood Pressure Intervention Trial with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m², measurements of urinary concentrations of interleukin-18 (IL-18), kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, monocyte chemoattractant protein-1, and chitinase-3-like protein-1 (YKL-40) were obtained at baseline. They assessed biomarker links with CVD events and all-cause mortality by using Cox proportional hazards models. A higher risk of mortality, but not CVD, was found in relation to higher urinary IL-18 and YKL-40 among hypertensive trial participants with CKD.