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Uric acid is an independent risk factor for decline in kidney function, cardiovascular event and mortality in patients with type 1 diabetes

Diabetes Care Mar 22, 2019

Pilemann-Lyberg S, et al. – Researchers sought to improve the strength and precision of the predictive value of uric acid for the risk of kidney function decline, cardiovascular events (CVEs), and mortality in patients with type 1 diabetes. In 670 patients with T1D and different degrees of albuminuria, plasma UA was measured, ranging from normoalbuminuria to macroalbuminuria. A doubling in UA level was related to a higher risk of estimated glomerular filtration rate decline of ≥ 30%, CVE, and mortality in adjusted analyses. A higher UA level was related to a higher risk of kidney function decline, CVE, and mortality in people with T1D, regardless of other risk factors. Among people with T1D, UA appeared to have a promising role in risk stratification.

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