Untreated hypertension and subsequent incidence of colorectal cancer: Analysis of a nationwide epidemiological database
Journal of the American Heart Association Nov 06, 2021
Kaneko H, Yano Y, Itoh H, et al. - A higher risk for incident colorectal cancer (CRC) was observed in relation to higher systolic blood pressure (SBP) and diastolic blood pressure (DBP), and stage 2 hypertension. This observation was true even for those without shared risk factors for CRC. People carrying an elevated risk for subsequent CRC could be identified through blood pressure (BP) measurements.
A nationwide health claims database was used to include participants with normal BP (n=1,164,807), elevated BP (n=341,273), stage 1 hypertension (n=466,298), or stage 2 hypertension (n=247,734).
Relative to normal BP, hazard ratios for incident CRC were 0.93 for increased BP, 1.07 for stage 1 hypertension, and 1.17 for stage 2 hypertension following multivariable adjustment.
For each 10‐mm Hg‐higher SBP or DBP, the estimated hazard ratios for incident CRC were 1.04 and 1.06, respectively.
These links existed in adults who did not have obesity, high waist circumference, diabetes, or dyslipidemia.
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