Lipton RB, Munjal S, Buse DC, et al. - Researchers examined data of a sample of US adults using oral, acute prescription migraine medications from Migraine in America Symptoms and Treatment (MAST) Study in order to characterize the unmet treatment needs among persons with migraine. US adults who met migraine symptom criteria and experienced 1 or more recent attacks were included in the MAST Study, a cross-sectional and longitudinal Web-based study. Respondents who self-reported a history of 3 or more monthly headache days (MHDs) in the past 3 months and at least 1 MHD in the past 30 days, and current use of orally administered acute prescription medication for headache, were included in this paper (n = 15,133). At least 1 area of unmet need was reported by an overwhelming majority of participants (95.8%). Nearly 90% of respondents reported attack-related unmet needs, and nearly 3 quarters of the sample (74.1%) had unmet needs related to inadequate treatment response. The attack-related and treatment response domains, in particular rapid onset of attack (65.3% of respondents), headache-related disability (55.6%), headache associated with sleep (49.7% inadequate 2-hour pain freedom (48.1%), and recurrence within 24 hours of initial relief (38%), were the most common areas of unmet need. This sample of oral medication users had a high occurrence of rapid attack onset and the broader population of persons with migraine who may use non-oral forms of medication might have this even more common. The burden of this attack-related unmet need may be reduced with a more widespread use of subcutaneously administered sumatriptan.